![]() NF‐κB signaling dynamics play a key role in infection control in tuberculosis. Relative importance of NF‐kappaB p50 in mycobacterial infection. Yamada H, Mizuno S, Reza‐Gholizadeh M, Sugawara I. Induction of pro‐inflammatory cytokines (IL‐1 and IL‐6) and lung inflammation by Coronavirus‐19 (COVI‐19 or SARS‐CoV‐2): anti‐inflammatory strategies. ![]() The determination of the perceived stress levels and health‐protective behaviors of nursing students during the COVID‐19 pandemic. Mycobacterium tuberculosis SARS-COV-2 pathogenesis prognosis tuberculin skin test.Įrsin F, Kartal M. TST positivity is favorably associated with the course of COVID-19. COVID-19 patients with positive TST showed a significantly higher rate of mild disease than those with negative TST. The maximum Youden J index value was 0.522 at an induration diameter of 6.5 mm, which had a sensitivity of 66.0% and specificity of 86.2%. The area under the receiver operating characteristic (ROC) curve of TST induration size for the differentiation of mild with moderate and severe disease was 0.768 (p < 0.001). Patients with mild disease had a significantly higher TST positivity rate (p < 0.001) and larger induration diameter (p < 0.001). All TST-positive patients had mild disease. COVID-19 severity was mild in 47 patients (61.8%), moderate in 22 patients (28.9%), and severe in seven patients (9.3%). ![]() Of the 76 patients, TST results were negative for 53 patients (69.7%) and positive for 23 patients (30.3%). Relationships between COVID-19 clinical severity and TST positivity, induration size, and other clinical parameters were analyzed. Of 1963 adult patients who underwent TST, 76 patients with SARS-COV-2 infection confirmed by RT-PCR analysis of respiratory tract samples were included in the study. This study investigated the relationship between tuberculin skin test (TST) induration diameter and the clinical course of COVID-19. As severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has a similar pathogenetic pathway to Mycobacterium tuberculosis, it has been reported that there may be a relationship between Bacille Calmette-Guérin (BCG) vaccination rate and COVID-19 severity. The pathogenesis of coronavirus disease 2019 (COVID-19) is still not fully understood. ![]()
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